Clinical significance of nephrotoxicity in patients treated with amphotericin B for suspected or proven aspergillosis
| Autor: | Lily Lee, John W. Hiemenz, John R. Wingard, Gary C. Yee, Louise Walshe, Elias Anaissie, Paul Kubilis, Raleigh A. Bowden, John Lister, Mary H. White |
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| Rok vydání: | 1999 |
| Předmět: |
Microbiology (medical)
Adult Male medicine.medical_specialty Antifungal Agents Time Factors Adolescent medicine.medical_treatment Aspergillosis Gastroenterology Nephrotoxicity chemistry.chemical_compound Renal Dialysis Internal medicine Amphotericin B medicine Humans Risk factor Survival rate Dialysis Aged Bone Marrow Transplantation Proportional Hazards Models Retrospective Studies Aged 80 and over Creatinine business.industry Hazard ratio Organ Transplantation Middle Aged medicine.disease Surgery Survival Rate Infectious Diseases chemistry Multivariate Analysis Drug Evaluation Female Kidney Diseases Hemodialysis business |
| Zdroj: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 29(6) |
| ISSN: | 1058-4838 |
| Popis: | The records of 239 immunosuppressed patients receiving amphotericin B for suspected or proven aspergillosis were reviewed to determine rates of nephrotoxicity, dialysis, and fatality. The mean and median durations of treatment were 20.4 and 15.0 days, respectively. The creatinine level doubled in 53% of patients and exceeded 2.5 mg/dL in 29%; 14.5% underwent dialysis; and 60% died. A multivariate Cox proportional hazards analysis showed that patients whose creatinine level exceeded 2.5 mg/dL (hazard ratio [HR], 42.02; P |
| Databáze: | OpenAIRE |
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