Local infectious complications following large joint replacement in rheumatoid arthritis patients treated with methotrexate versus those not treated with methotrexate
| Autor: | Allen M. Segal, William S. Wilke, John D. Clough, Robert S. Perhala |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
musculoskeletal diseases
Adult Male Reoperation medicine.medical_specialty medicine.medical_treatment Immunology Prosthesis Arthritis Rheumatoid Folic Acid Rheumatology Adrenal Cortex Hormones Surgical Wound Dehiscence medicine Poor wound healing Immunology and Allergy Humans Surgical Wound Infection Pharmacology (medical) Aged Retrospective Studies Autoimmune disease Aged 80 and over Chemotherapy business.industry Incidence Perioperative Middle Aged medicine.disease Surgery Methotrexate Rheumatoid arthritis Prednisone Drug Therapy Combination Female business Complication Knee Prosthesis medicine.drug |
| Zdroj: | Arthritis and rheumatism. 34(2) |
| ISSN: | 0004-3591 |
| Popis: | We performed a 10-year retrospective analysis of the frequency of local postoperative infectious complications in methotrexate (MTX)-treated rheumatoid arthritis patients who underwent total joint arthroplasty. Sixty patients, who had a total of 92 joint arthroplasties, were receiving MTX. A comparison group of 61 patients with a combined total of 110 total joint arthroplasties were not receiving MTX. The 2 groups were compared for the occurrence of local postoperative infectious complications and poor wound healing. Eight patients in the MTX group experienced a total of 8 complications (8.7% of procedures). In comparison, 5 patients in the non-MTX group experienced a total of 6 complications (5.5% of procedures), a difference that was not statistically significant (chi 2 = 0.816, P = 0.366). Statistical analysis of many other variables revealed none that could be identified as risk factors for postoperative complications. These results suggest that treatment in the perioperative period with weekly low-dose pulse MTX does not increase the risk of local postoperative infectious complications or poor wound healing in rheumatoid arthritis patients who undergo total joint arthroplasty. |
| Databáze: | OpenAIRE |
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