The prognostic and predictive value of sstr2-immunohistochemistry and sstr2-targeted imaging in neuroendocrine tumors
| Autor: | Ann-Catherine Jörg, Philippe Brunner, Anja Schmitt, Helmut R. Maecke, Aurel Perren, Nicolas Marincek, Rebecca A. Dumont, Petar Marko Spanjol, Katharina Glatz, Matthias Briel, Piotr Radojewski, Lukas Bubendorf, Jan Müller-Brand, Martin A. Walter, Thomas Krause, Maria Umlauft |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Pathology Multivariate analysis medicine.medical_treatment 610 Medicine & health Neuroendocrine tumors Targeted therapy 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Somatostatin receptor 2 Radiology Nuclear Medicine and imaging Survival analysis Tissue microarray business.industry General Medicine medicine.disease Radiation therapy 030104 developmental biology 030220 oncology & carcinogenesis 570 Life sciences biology Immunohistochemistry business |
| Zdroj: | Brunner, Philippe; Jörg, Ann-Catherine; Glatz, Katharina; Bubendorf, Lukas; Radojewski, Piotr; Umlauft, Maria; Marincek, Nicolas; Spanjol, Petar Marko; Krause, Thomas Michael; Dumont, Rebecca A; Maecke, Helmut R; Müller-Brand, Jan; Briel, Matthias; Schmitt, Anja; Perren, Aurel; Walter, Martin Alexander (2017). The prognostic and predictive value of sstr2-immunohistochemistry and sstr2-targeted imaging in neuroendocrine tumors. European journal of nuclear medicine and molecular imaging, 44(3), pp. 468-475. Springer 10.1007/s00259-016-3486-2 |
| ISSN: | 1619-7089 1619-7070 |
| Popis: | PURPOSE Our aim was to assess the prognostic and predictive value of somatostatin receptor 2 (sstr2) in neuroendocrine tumors (NETs). METHODS We established a tissue microarray and imaging database from NET patients that received sstr2-targeted radiopeptide therapy with yttrium-90-DOTATOC, lutetium-177-DOTATOC or alternative treatment. We used univariate and multivariate analyses to identify prognostic and predictive markers for overall survival, including sstr2-imaging and sstr2-immunohistochemistry. RESULTS We included a total of 279 patients. In these patients, sstr2-immunohistochemistry was an independent prognostic marker for overall survival (HR: 0.82, 95 % CI: 0.67 - 0.99, n = 279, p = 0.037). In DOTATOC patients, sstr2-expression on immunohistochemistry correlated with tumor uptake on sstr2-imaging (n = 170, p |
| Databáze: | OpenAIRE |
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