Accelerated Hypertension in the Rat: Relation between Renin, Renal Vascular Lesions, Salt Intake and Blood Pressure
| Autor: | A. S. P. Hua, Sauwaluck Chusilp, Priscilla Kincaid-Smith |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Mean arterial pressure
medicine.medical_specialty Blood Pressure Sodium Chloride Plasma renin activity Renal Artery Internal medicine medicine.artery Renin Renin–angiotensin system Animals Medicine Salt intake Renal artery Aorta business.industry General Medicine Diet Rats Endocrinology medicine.anatomical_structure Blood pressure Hypertension Cardiology business Interlobular arteries |
| Zdroj: | Clinical Science. 51:69s-71s |
| ISSN: | 0144-4107 |
| DOI: | 10.1042/cs051069s |
| Popis: | 1. Complete ligation of the aorta between the origins of the two renal arteries in the rat produces a predictable form of accelerated hypertension. Changes in the blood pressure, plasma renin activity and renal histological lesions have been studied. 2. Group 1 rats and their control group (group 2) received tap water, and group 3 and its control group (group 4) received sodium chloride solution (0·154 mol/l) in place of tap water, for 4 weeks before aortic ligation. In the experimental groups 1 and 3, complete ligation was carried out. In groups 2 and 4 the aorta and renal arteries were exposed, but not ligated. Interlobular artery lesions were studied on a blind basis and graded 0–4 according to severity. 3. Groups 1 and 3 developed severe hypertension. In group 1 the raised mean arterial pressure showed a significant correlation with increased plasma renin activity. Both mean arterial pressure and plasma renin activity also showed a significant correlation with changes in interlobular arteries. In group 3 the raised mean arterial blood pressure did not show a significant correlation with the depressed plasma renin activity, or with changes in interlobular arteries. A significant correlation was, however, found between plasma renin activity and interlobular artery lesions in group 3. 4. These results suggest that the renin-angiotensin system may influence renal vascular lesions through some mechanism independent of the blood pressure. |
| Databáze: | OpenAIRE |
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