Elimination of antithrombin III concentrate in healthy pregnant and preeclamptic women with an acquired antithrombin III deficiency
| Autor: | Carl P. Weiner, James E. Herrig, Gay D. Pelzer, Joni Heilskov |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
Antithrombin III Normal pregnancy Preeclampsia Pre-Eclampsia Pharmacokinetics Pregnancy Reference Values Internal medicine medicine Humans Antithrombin III Deficiency business.industry Antithrombin Antithrombin III deficiency Biological activity Hematology medicine.disease Surgery Endocrinology Regression Analysis Gestation Female business Half-Life medicine.drug |
| Zdroj: | Thrombosis Research. 58:395-401 |
| ISSN: | 0049-3848 |
| DOI: | 10.1016/0049-3848(90)90210-4 |
| Popis: | The activity elimination half-life of heat-treated antithrombin III (AT III) concentrate was studied in 5 healthy pregnant and 5 preeclamptic women with a documented AT III deficiency. Healthy pregnant women received 1500 units over 20 minutes. Serial blood specimen; were obtained over the next 12 hours. The mean (± SEM) activity elimination half-life of AT III was 29.4h ± 3.4h. Preeclamptic subjects had a mean baseline AT III activity of 70.5 ± 2% (range 61 to 75%). Their activity eliminatior half-life after 3000 units of AT III concentrate was 8.5 ± 1.2h. There was a direct relationship between the pre-concentrate AT III activity level and the AT III activity elimination half-life (r = 0.79, p = 0.01) for all subjects. Based upon parameters calculated from the first infusion, the AT III activity of preeclamptic subjects was maintained by a constant infusion at approximately 100% for 96h. At the conclusion of the infusion, the activity elimination half-life was again measured. A dramatic increase in the activity elimination half-life was demonstrated (433.6h). We conclude that the activity elimination half-life of AT III concentrate is increased during normal pregnancy and further increased in preeclamptic women with an acquired deficiency. |
| Databáze: | OpenAIRE |
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