c-myc oncogene expression and clinical outcome in carcinoma of the cervix
| Autor: | Anuradha Sowani, John O. White, Jonathan Waxman, Stanley Dische, Karol Sikora, Gloria Ong, Cecily Quinn, Pat Soutter |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Cervical cancer
Intraepithelial neoplasia Oncogene medicine.diagnostic_test Uterine Cervical Neoplasms Cell Biology Biology Prognosis medicine.disease Immunohistochemistry Proto-Oncogene Proteins c-myc Gene product medicine.anatomical_structure Gene Expression Regulation Proto-Oncogene Proteins Biopsy Carcinoma medicine Cancer research Humans Female Stage (cooking) Molecular Biology Cervix |
| Zdroj: | Molecular and Cellular Probes. 3:117-123 |
| ISSN: | 0890-8508 |
| DOI: | 10.1016/0890-8508(89)90022-4 |
| Popis: | The expression of the c-myc oncogene was studied in paraffin-embedded specimens of cervical biopsies using a monoclonal antibody which binds to the 62,000 Dalton protein encoded by the c-myc gene. A range of cervical cancers from intraepithelial neoplasia to advanced grade IV tumours were studied together with normal cervical biopsies; c-myc status was correlated to clinical progress. There was no correlation seen between the clinical stage of the disease at presentation and c-myc expression. The 15 patients with c-myc negative cervical cancers were shown to have better disease free (mean—95·4 mos) and total survival (mean 118·0—mos) compared to the 16 patients that were c-myc positive 28·4 and 48·4 mos respectively). The pattern of recurrence differed between the two groups with c-myc positive tumours more likely to develop extra pelvic metastatic disease. The c-myc status of cervical cancer offers a prognostic indicator that could be useful in guiding treatment decisions. |
| Databáze: | OpenAIRE |
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