E-type prostaglandins: a new emergency therapy for certain cyanotic congenital heart malformations
| Autor: | Peter M. Olley, F. Coceani, E. Bodach |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Heart Defects
Congenital Male congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Heart malformation Cyanotic congenital heart disease Physiology (medical) Ductus arteriosus Internal medicine Preoperative Care medicine Humans Pulmonary blood flow In patient cardiovascular diseases Prostaglandin a business.industry Prostaglandins E Palliative Care Infant Newborn Ductus Arteriosus Dilatation Shunt (medical) Oxygen medicine.anatomical_structure Evaluation Studies as Topic Anesthesia cardiovascular system Cardiology Blood supply Cardiology and Cardiovascular Medicine business |
| Zdroj: | Circulation. 53:728-731 |
| ISSN: | 1524-4539 0009-7322 |
| DOI: | 10.1161/01.cir.53.4.728 |
| Popis: | Prostaglandin E2 (PGE2) has been used to maintain patency of the ductus arteriosus in four neonates with cyanotic congenital heart disease due to obstructive right heart malformations. PGE2 was infused prior to surgery, and in three patients, during surgery until a satisfactory aorto-pulmonary shunt was established. PGE2 produced consistently an immediate and persistent rise in arterial oxygen saturation, which could be ascribed to dilation of the ductus arteriosus. No major side effects occurred, except for pyrexia in two infants. All patients recovered well from surgery. We propose this treatment as preparation for surgery in any infant with congenital heart defects and ductus-dependent pulmonary blood flow. The same treatment may be useful preoperatively in patients with aortic interruption who also depend on continued patency of the ductus for blood supply to the lower half of the body. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|