A randomized multicentric study comparing alternating combination chemotherapy (VCMP/VBAP) and melphalan-prednisone in multiple myeloma
| Autor: | Jesús E. Maldonado, R. Jimenez Galindo, Marissa Daniels, Moro Mj, J. Bladé, Carmen Alonso, Juan Sanchis, Jordi Estapé, Carles Besses, Albert Domingo, J. Fernández Calvo, J. Tortosa, Rozman C, M. V. Faura, J. M. Hernández Martín, Javier García-Conde, Francisco Ortega, A Alcalá, Juan Besalduch, L. Hernandez Nieto, J F San Miguel, Mayans J, Daniel Rubio, A. Zubizarreta, M. A. Sanz Sanz |
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| Rok vydání: | 1990 |
| Předmět: |
Melphalan
Male medicine.medical_specialty Vincristine Cyclophosphamide medicine.medical_treatment Gastroenterology Drug Administration Schedule Prednisone Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Multicenter Studies as Topic Prospective Studies Survival analysis Multiple myeloma Randomized Controlled Trials as Topic Chemotherapy business.industry Combination chemotherapy Hematology General Medicine Middle Aged medicine.disease Carmustine Surgery Doxorubicin Female business Multiple Myeloma medicine.drug |
| Zdroj: | Blut. 60(6) |
| ISSN: | 0006-5242 |
| Popis: | Between January 1985 and December 1988, 386 patients with multiple myeloma were randomized to receive either MP or combination chemotherapy based on alternating cycles of VCMP and VBAP. The major prognostic parameters did not differ significantly between both treatment groups. A significantly higher proportion of objective responses was observed with combination chemotherapy as compared to MP (47.8 vs 32.2, P = 0.01). The median survival for all patients was 33.5 months. So far no significant differences were found when comparing the survival curves from both groups of patients. However, the median survival of MP-treated patients is 26.8 months, whereas the median survival of patients receiving VCMP/VBAP has not yet been reached. The definitive analysis must await the evaluation of all patients entered into the study and a longer follow-up time. |
| Databáze: | OpenAIRE |
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