The Important Role of Metal Ions for Survival of Francisella in Water within Amoeba Environment
| Autor: | Marija Ćurlin, Danijela Lenac, Paula Zurga, Marina Šantić, Masa Knezevic, Valentina Marečić, Vanda Piškur, Aleksandar Bulog, Mateja Ozanic, Andrea Majstorovic |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Article Subject Growth kinetics Metal ions in aqueous solution 030106 microbiology Environment General Biochemistry Genetics and Molecular Biology Amoeba (operating system) Microbiology Tularemia 03 medical and health sciences BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Medical Microbiology medicine Francisella Amoeba Francisella tularensis Ions General Immunology and Microbiology biology Chemistry Francisella novicida amoeba zinc manganese Metal Intracellular parasite Water General Medicine biology.organism_classification medicine.disease bacterial infections and mycoses 6. Clean water 030104 developmental biology Medicine Bacteria BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Medicinska mikrobiologija |
| Zdroj: | BioMed Research International Volume 2021 BioMed Research International, Vol 2021 (2021) |
| ISSN: | 2314-6133 |
| Popis: | Francisella tularensis is a gram-negative facultative intracellular bacterium that resists harsh environments. Several outbreaks of tularemia are linked to the consumption and contact with spring water. The number of F. tularensis in some waters is high, while in others, this bacterium does not survive. Except organic compounds, metals could be important for the survival of F. tularensis in water. Some Francisella strains showed the association with amoeba, which may act as the environmental reservoir. This study was aimed at following the role of metal ions and/or amoeba in the existence and replication of F. novicida in spring waters by growth kinetics, acquisition of metals, and ultrastructural analyses of bacteria. The bacteria showed a longer survival in water with higher initial concentrations of Mn and Zn. Although Mn and Zn were necessary for the survival of F. novicida, the results also showed that the bacterium does not grow in water with high levels of Zn. In contrast, high levels of Mn did not have such a negative effect on the survival of this bacterium in water. In addition, while F. novicida benefits presence of amoeba in spring water, the number of amoebae is decreasing in a coculture model with F. novicida. |
| Databáze: | OpenAIRE |
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