Plasma homovanillic acid, plasma anti-D1 and -D2 dopamine-receptor activity, and negative symptoms in chronically medicated schizophrenia
| Autor: | Hiroki Koshikawa, Eiji Suzuki, Masashi Nibuya, Gohei Yagi, Toshio Nakai, Shigenobu Kanba |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Psychosis Receptors Dopamine chemistry.chemical_compound Dopamine receptor D2 Internal medicine Humans Medicine skin and connective tissue diseases Scale for the Assessment of Negative Symptoms Biological Psychiatry Psychiatric Status Rating Scales Dose-Response Relationship Drug Receptors Dopamine D2 business.industry Receptors Dopamine D1 Homovanillic acid Dopamine antagonist Brain Middle Aged medicine.disease Hospitalization Dose–response relationship Endocrinology chemistry Dopamine receptor Schizophrenia Catecholamine Female Schizophrenic Psychology sense organs business Antipsychotic Agents medicine.drug |
| Zdroj: | Biological Psychiatry. 31:357-364 |
| ISSN: | 0006-3223 |
| DOI: | 10.1016/0006-3223(92)90229-s |
| Popis: | We have investigated the relationship between the concentration of homovanillic acid in human plasma (pHVA) and plasma anti-D1 and anti-D2 dopamine receptor activity in chronic schizophrenic patients whose neuroleptic dosage was changed. The change in pHVA level correlated with that in anti-D1, not anti-D2 activity, thus suggesting that the neuroleptic-induced changes in pHVA concentration may be associated with the blocking of D1- as well as D2- receptors. The change of scores on the Scale for the Assessment of Negative Symptoms did not significantly correlate with changes in anti-D1 or anti-D2 activity, but did so correlated with the change in pHVA level. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|