Generation of integration-free induced pluripotent stem cells (GZHMUi001-A) by reprogramming peripheral blood mononuclear cells from a 47, XXX syndrome patient
| Autor: | Yexing Xian, Zhanhui Ou, Xiaofang Sun, Yanting Xue, Yuchang Chen, Shuming Ouyang, Yuhuan Xie, Bing Song |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Induced Pluripotent Stem Cells Sex Chromosome Disorders of Sex Development Cell Culture Techniques Trisomy Syndrome patient Peripheral blood mononuclear cell Young Adult 03 medical and health sciences medicine Humans Induced pluripotent stem cell lcsh:QH301-705.5 Sex Chromosome Aberrations X chromosome Chromosomes Human X biology Cell Biology General Medicine Cellular Reprogramming biology.organism_classification medicine.disease Sendai virus Premature ovarian failure 030104 developmental biology lcsh:Biology (General) Immunology Leukocytes Mononuclear Cancer research Female Reprogramming Developmental Biology |
| Zdroj: | Stem Cell Research, Vol 23, Iss C, Pp 57-60 (2017) |
| ISSN: | 1876-7753 1873-5061 |
| Popis: | 47, XXX syndrome is one of several sex-chromosomal aneuploidies, and it has an incidence of approximately 1/1000 in newborn females. Because of heterogeneity in X-inactivation, these patients may exhibit a variety of clinical symptoms. Here, we report the generation of an integration-free human induced pluripotent stem cell line (GZHMUi001-A) by using Sendai virus to reprogram peripheral blood mononuclear cells from a 47, XXX syndrome patient with premature ovarian failure. This 47, XXX iPS cell line has characteristics of pluripotent stem cells and is a useful tool for the investigation of this X chromosome aneuploid disease. |
| Databáze: | OpenAIRE |
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