Self-expandable Esophageal Stent Loaded with125I Seeds: Initial Experience in Patients with Advanced Esophageal Cancer
Autor: | Guo-Zhao Li, Shi-Cheng He, Wen Fang, Gang Deng, Jin-He Guo, Gao-Jun Teng, Guang-Yu Zhu |
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Rok vydání: | 2008 |
Předmět: |
Male
medicine.medical_specialty Esophageal Neoplasms Iohexol medicine.medical_treatment Brachytherapy Contrast Media Prosthesis Design Radiography Interventional Statistics Nonparametric Iodine Radioisotopes Esophageal stent Informed consent medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies cardiovascular diseases Esophagus Aged Aged 80 and over Esophageal disease business.industry Stent Cancer Middle Aged Esophageal cancer equipment and supplies medicine.disease Dysphagia Surgery Treatment Outcome surgical procedures operative medicine.anatomical_structure Fluoroscopy Female Stents medicine.symptom Deglutition Disorders business |
Zdroj: | Radiology. 247:574-581 |
ISSN: | 1527-1315 0033-8419 |
Popis: | To prospectively compare the response to treatment with a self-expandable esophageal stent loaded with iodine 125 ((125)I) seeds for intraluminal brachytherapy versus the response to treatment with a conventional self-expandable covered stent in patients with advanced esophageal cancer.The study protocol was approved by the institutional ethics committee, and informed consent was obtained from each patient. Patients from one institution who had dysphagia caused by inoperable esophageal cancer were randomly assigned to receive treatment with a stent loaded with (125)I seeds (irradiation stent group) or a conventional covered stent (control group). After stent implantation, the outcomes were measured in terms of relief of dysphagia, survival time, and complications related to the procedure. Dysphagia was assigned a grade. A P value of less than .05 was considered to indicate a significant difference.The stent was successfully placed in the diseased esophagus in all 53 patients (27 patients in the irradiation stent group and 26 patients in the control group). The dysphagia grades significantly improved in both groups within the 1st month after stent placement but were better in the irradiation stent group than in the control group after 2 months (P.05). The median and mean survival times were better in the irradiation stent group than in the control group, and the differences were significant (P.001). Hemorrhage occurred in 16 (30%) patients in both groups combined during follow-up.In patients with advanced esophageal cancer, treatment with an esophageal stent loaded with (125)I seeds, compared with that with a conventional covered stent, has potential benefit in that it allows a slightly longer relief of dysphagia and extended survival. |
Databáze: | OpenAIRE |
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