Synthesis of a TRPV1 Receptor Antagonist
| Autor: | Brian Kotecki, Su Yu, Anthony Haight, Lei Wang, David R. Hill, Kirill Lukin |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
inorganic chemicals
Analgesics Indazoles Magnetic Resonance Spectroscopy Stereochemistry Chemistry Organic Chemistry Antagonist TRPV Cation Channels Sonogashira coupling chemistry.chemical_element Amides Chemical synthesis Combinatorial chemistry Catalysis chemistry.chemical_compound Benzyl Compounds Urea heterocyclic compounds Palladium TRPV1 receptor |
| Zdroj: | Synfacts. 2010:0393-0393 |
| ISSN: | 1861-194X 1861-1958 |
| DOI: | 10.1055/s-0029-1219494 |
| Popis: | A five-step synthesis of a TRPV1 receptor antagonist 1 is described. The key step involves a novel palladium-catalyzed amidation reaction of 4-chloro-1-methylindazole 8 with the benzyl urea 9 to form the unsymmetrically substituted urea 1. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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