Poor outcome of myeloablative conditioned allogeneic bone marrow transplantation for myelofibrosis
| Autor: | Hideki Akiyama, Yuka Hirashima, Masahide Yamamoto, Kazuhiko Kakihana, Takeshi Kobayashi, Hisashi Sakamaki, Kazuteru Ohashi |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Transplantation Conditioning medicine.medical_treatment Hematopoietic stem cell transplantation Recurrence Risk Factors Internal medicine Internal Medicine medicine Humans Transplantation Homologous Single institution Autogenous bone Myelofibrosis Retrospective Studies Marrow transplantation business.industry Myeloablative conditioning Hematopoietic Stem Cell Transplantation General Medicine Middle Aged medicine.disease Treatment Outcome International Prognostic Scoring System Primary Myelofibrosis Female business |
| Zdroj: | Internal medicine (Tokyo, Japan). 51(10) |
| ISSN: | 1349-7235 |
| Popis: | OBJECTIVE This study retrospectively analyzed clinical outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for myelofibrosis (MF) in a single institution. METHODS During the past 20 years, 6 patients with MF have undergone allo-HSCT in our institution. We investigated the clinical characteristics and follow-up course of these patients. PATIENTS Median age was 47 years (range, 40-52 years). The median interval between diagnosis and allo-HSCT was 12.5 months (range, 5-97 months). RESULTS Among these 6 patients, 4 patients were categorized in the high-risk group according to the International Prognostic Scoring System. All 6 patients received myeloablative conditioning regimens, but most of them eventually died of relapse. CONCLUSION In this small series, allo-HSCT resulted in dismal outcomes. Our experience clearly indicates the need for studies with a larger series of patients to evaluate the efficacy of this modality. |
| Databáze: | OpenAIRE |
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