Late onset Leber's optic neuropathy: a case confused with ischaemic optic neuropathy
| Autor: | M. D. Sanders, François-Xavier Borruat, M G Sweeney, J A Morgan-Hughes, E M Graham, W T Green |
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| Rok vydání: | 1992 |
| Předmět: |
Male
Pathology medicine.medical_specialty genetic structures Eye disease Late onset Fundus (eye) DNA Mitochondrial Diagnosis Differential Optic neuropathy Cellular and Molecular Neuroscience Optic Atrophies Hereditary medicine Humans Fluorescein Angiography medicine.diagnostic_test business.industry Optic Nerve Magnetic resonance imaging Middle Aged medicine.disease Fluorescein angiography Magnetic Resonance Imaging eye diseases Sensory Systems Optic Atrophy Ophthalmology Optic nerve sense organs Differential diagnosis business Research Article |
| Zdroj: | British Journal of Ophthalmology. 76:571-573 |
| ISSN: | 0007-1161 |
| DOI: | 10.1136/bjo.76.9.571 |
| Popis: | A case is reported of a 63-year-old man with progressive central visual loss in one eye followed 11 months later by involvement of the fellow eye. A diagnosis of chronic ischaemic optic neuropathy was considered. However, despite a negative family history, the absence of electrocardiographic abnormalities, and minimal fundus changes a diagnosis of Leber's optic neuropathy was made on the basis of magnetic resonance imaging findings and the mitochondrial DNA mutation at base pair 11778. |
| Databáze: | OpenAIRE |
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