Effects of in utero tributyltin chloride exposure in the rat on pregnancy outcome
| Autor: | Daming Li, Gerard M. Cooke, Jacquetta M. Trasler, Don Forsyth, Johanna Barthelemy, Adedayo Adeeko, Valerie Casey, Daniel G. Cyr, Bernard Robaire, Barbara F. Hales |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Sternum Litter Size Developmental toxicity Administration Oral Anal Canal Biology Genitalia Male Toxicology Weight Gain Rats Sprague-Dawley chemistry.chemical_compound Embryonic and Fetal Development Pregnancy Internal medicine medicine Animals Embryo Implantation Sex Characteristics Triiodothyronine Dose-Response Relationship Drug Reproduction Rats Thyroxine Endocrinology chemistry Endocrine disruptor In utero Maternal Exposure Toxicity Tributyltin Gestation Environmental Pollutants Female Trialkyltin Compounds Reproductive toxicity |
| Zdroj: | Toxicological sciences : an official journal of the Society of Toxicology. 74(2) |
| ISSN: | 1096-6080 |
| Popis: | Tributyltin, an organotin, is ubiquitous in the environment. The consumption of contaminated marine species leads to human dietary exposure to this compound. Tributyltin is an endocrine disruptor in many wildlife species and inhibits aromatase in mam- malian placental and granulosa-like tumor cell lines. We investi- gated the effects of tributyltin chloride exposure on pregnancy outcome in the Sprague-Dawley rat. Timed pregnant rats were gavaged either with vehicle (olive oil) or tributyltin chloride (0.25, 2.5, 10, or 20 mg/kg) from days 0 -19 or 8 -19 of gestation. On gestational day 20, dams were sacrificed, and pregnancy outcome was determined. Tributyltin and its metabolites (dibutyltin, monobutyltin) were measured in maternal blood by gas chroma- tography. Both tributyltin and dibutyltin were present in maternal blood at approximately equal concentrations, whereas monobutyl- tin contributed minimally to total organotins. Organotin con- centrations increased in a dose-dependent pattern in dams, independent of the window of exposure. Tributyltin chloride ad- ministration significantly reduced maternal weight gain only at the highest dose (20 mg/kg); a significant increase in post-implan- tation loss and decreased litter sizes, in addition to decreased fetal weights, was observed in this group. Tributyltin chloride exposure did not result in external malformations, nor was there a change in sex ratios. However, exposure to 0.25, 2.5, or 10 mg/kg tributyltin chloride from gestation days (GD) 0 -19 resulted in a significant increase in normalized anogenital distances in male fetuses; expo- sure from days 8 -19 had no effect. There was a dramatic increase in the incidence of low weight ( |
| Databáze: | OpenAIRE |
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