Searching for host immune-microbiome mechanisms in obsessive-compulsive disorder: A narrative literature review and future directions
| Autor: | Emily A. Troyer, Suzi Hong, Gajender Aleti, David R. Rosenberg, Jordan N. Kohn, Gertrude Ecklu-Mensah |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Obsessive-Compulsive Disorder
Cognitive Neuroscience Gut flora behavioral disciplines and activities Article Behavioral Neuroscience Immune system Treatment targets Obsessive compulsive Immunity mental disorders Medicine Animals Microbiome Neuroinflammation biology business.industry Microbiota Brain biochemical phenomena metabolism and nutrition biology.organism_classification Gut microbiome Gastrointestinal Microbiome Neuropsychology and Physiological Psychology bacteria business Neuroscience |
| Zdroj: | Neurosci Biobehav Rev |
| Popis: | Obsessive-compulsive disorder (OCD) is disabling and often treatment-refractory. Host immunity and gut microbiota have bidirectional communication with each other and with the brain. Perturbations to this axis have been implicated in neuropsychiatric disorders, but immune-microbiome signaling in OCD is relatively underexplored. We review support for further pursuing such investigations in OCD, including: 1) gut microbiota has been associated with OCD, but causal pathogenic mechanisms remain unclear; 2) early environmental risk factors for OCD overlap with critical periods of immune-microbiome development; 3) OCD is associated with increased risk of immune-mediated disorders and changes in immune parameters, which are separately associated with the microbiome; and 4) gut microbiome manipulations in animal models are associated with changes in immunity and some obsessive-compulsive symptoms. Theoretical pathogenic mechanisms could include microbiota programming of cytokine production, promotion of expansion and trafficking of peripheral immune cells to the CNS, and regulation of microglial function. Immune-microbiome signaling in OCD requires further exploration, and may offer novel insights into pathogenic mechanisms and potential treatment targets for this disabling disorder. |
| Databáze: | OpenAIRE |
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