Suggested Case of Langerhans Cell Histiocytosis in a Cretaceous dinosaur
| Autor: | Frank J Rühli, Darren H. Tanke, Ariel Pokhojaev, Hila May, Bruce M. Rothschild |
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| Přispěvatelé: | University of Zurich, Rothschild, Bruce M |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine lcsh:Medicine Diseases 610 Medicine & health Biology Article Dinosaurs Lesion 03 medical and health sciences Imaging Three-Dimensional 0302 clinical medicine Langerhans cell histiocytosis medicine Living creature Animals Humans lcsh:Science Pathological Phylogeny Cancer 1000 Multidisciplinary Multidisciplinary Ecology Fossils lcsh:R X-Ray Microtomography Anatomy medicine.disease Skeleton (computer programming) Spine Histiocytosis Langerhans-Cell 030104 developmental biology Child Preschool 11294 Institute of Evolutionary Medicine lcsh:Q medicine.symptom Zoology 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Susceptibility to diseases is common to humans and dinosaurs. Since much of the biological history of every living creature is shaped by its diseases, recognizing them in fossilized bone can furnish us with important information on dinosaurs’ physiology and anatomy, as well as on their daily activities and surrounding environment. In the present study, we examined the vertebrae of two humans from skeletal collections with Langerhans Cell Histiocytosis (LCH), a benign osteolytic tumor-like disorder involving mainly the skeleton; they were diagnosed in life, along with two hadrosaur vertebrae with an apparent lesion. Macroscopic and microscopic analyses of the hadrosaur vertebrae were compared to human LCH and to other pathologies observed via an extensive pathological survey of a human skeletal collection, as well as a three-dimensional reconstruction of the lesion and its associated blood vessels from a µCT scan. The hadrosaur pathology findings were indistinguishable from those of humans with LCH, supporting that diagnosis. This report suggests that hadrosaurids had suffered from larger variety of pathologies than previously reported. Furthermore, it seems that LCH may be independent of phylogeny. |
| Databáze: | OpenAIRE |
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