Fatty acid amide hydrolase substrate specificity
| Autor: | Robert A. Fecik, Jean E. Patterson, Matthew P. Patricelli, Dale L. Boger, Benjamin F. Cravatt, Hiroshi Miyauchi |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Oleamide
Stereochemistry Clinical Biochemistry Pharmaceutical Science Biochemistry Amidohydrolases Substrate Specificity chemistry.chemical_compound Fatty acid amide hydrolase Amide Drug Discovery Animals Molecular Biology Unsaturated fatty acid chemistry.chemical_classification Chemistry Hydrolysis Organic Chemistry Fatty acid Serine hydrolase Anandamide Recombinant Proteins Rats nervous system Saturated fatty acid Molecular Medicine lipids (amino acids peptides and proteins) psychological phenomena and processes |
| Zdroj: | Bioorganicmedicinal chemistry letters. 10(23) |
| ISSN: | 0960-894X |
| Popis: | Fatty acid amide hydrolase (FAAH), also referred to as oleamide hydrolase and anandamide amidohydrolase, is a serine hydrolase responsible for the degradation of endogenous oleamide and anandamide, fatty acid amides that function as chemical messengers. FAAH hydrolyzes a range of fatty acid amides, and the present study examines the relative rates of hydrolysis of a variety of natural and unnatural fatty acid primary amide substrates using pure recombinant rat FAAH. |
| Databáze: | OpenAIRE |
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