COVID-19 Infection: Targeting Possibilities for Treatment
| Autor: | Rahul Tiwari, Tanweer Haider, Sakshi Soni, Vishal Gour, Monika Vishwakarma, Arkadeep Sarkar, Vikas Pandey, Vandana Soni, Ravishankar Yadav, Avijit Kumar Bakshi, Indu Lata Kanwar |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
COVID-19 Vaccines medicine.drug_class Favipiravir medicine.disease_cause Antiviral Agents chemistry.chemical_compound Tocilizumab Pandemic medicine Humans Molecular Targeted Therapy Intensive care medicine Pandemics Coronavirus Viral Structural Proteins Clinical Trials as Topic Plant Extracts SARS-CoV-2 business.industry COVID-19 Outbreak International health Hydroxychloroquine Off-Label Use General Medicine COVID-19 Drug Treatment Treatment Outcome chemistry Mutation Drug Therapy Combination Angiotensin-Converting Enzyme 2 Antiviral drug business medicine.drug |
| Zdroj: | Critical Reviews™ in Therapeutic Drug Carrier Systems. 38:75-115 |
| ISSN: | 0743-4863 |
| Popis: | The outbreak of novel coronavirus (nCoV) or severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in December 2019 in Wuhan, China, has posed an international public health emergency worldwide and forced people to be confined in their homes. This virus is of high-risk category and is declared a pandemic by the World Health Organization (WHO). The worldwide researchers and various health professionals are working together to determine the best way to stop its spread or halt this virus's spread and circumvent this pandemic condition threatening millions of human lives. The absence of definitive treatment is possible to explore to reduce virus infection and enhance patient recovery. Along with off-label medicines, plasma therapy, vaccines, the researchers exploit the various plants/herbs and their constituents to effectively treat nCoV infection. The present study aimed to present brief and most informative salient features of the numerous facts regarding the SARS-CoV-2, including the structure, genomic sequence, recent mutation, targeting possibility, and various hurdles in research progress, and off-labeled drugs, convalescent plasma therapy, vaccine and plants/herbs for the treatment of coronavirus disease-2019 (COVID-19). Results showed that off-labeled drugs such as hydroxychloroquine, dexamethasone, tocilizumab, antiviral drug (remdesivir, favipiravir), etc., give positive results and approved for use or approved for restricted use in some countries like India. Future research should focus on these possibilities that may allow the development of an effective treatment for COVID-19. |
| Databáze: | OpenAIRE |
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