Successful treatment of varicella zoster virus retinitis with aggressive intravitreal and systemic antiviral therapy
| Autor: | H J Zambarakji, S M Mitchell, A A Obi |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Foscarnet Ganciclovir medicine.medical_specialty Pediatrics viruses Organophosphonates Retinitis medicine.disease_cause Antiviral Agents Cytosine chemistry.chemical_compound Therapeutic approach Organophosphorus Compounds Pharmacotherapy medicine Humans Immunology and Allergy Acquired Immunodeficiency Syndrome business.industry Varicella zoster virus virus diseases Retinal detachment biochemical phenomena metabolism and nutrition medicine.disease Surgery Vitreous Body Ophthalmology chemistry Injections Intravenous Herpes Zoster Ophthalmicus Drug Therapy Combination Female business Cidofovir medicine.drug |
| Zdroj: | Ocular Immunology and Inflammation. 10:41-46 |
| ISSN: | 1744-5078 0927-3948 |
| Popis: | Aims : To describe the successful treatment of varicella zoster virus retinitis (VZVR) using intravenous cidofovir as part of an aggressive management strategy. Case reports : Two patients with bilateral VZVR were treated with a combination of intravenous cidofovir and ganciclovir with adjuvant intravitreal foscarnet or ganciclovir. Both patients maintained good vision in the less severely affected eye. Retinal detachment did not occur in either patient. Conclusions : VZVR should be treated aggressively with a combination of intravenous and intravitreal therapy to improve visual prognosis. Intravenous cidofovir, in the absence of contra-indications, should be considered as part of this aggressive therapeutic approach, especially in patients with AIDS in whom the prognosis is particularly poor. |
| Databáze: | OpenAIRE |
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