Exosomes in Severe Asthma: Update in Their Roles and Potential in Therapy

Autor: Mortaz, Esmaeil, Alipoor, Shamila D, Varahram, Mohammad, Jamaati, Hamidreza, Garssen, Johan, Mumby, Sharon E, Adcock, Ian M, Afd Pharmacology, Pharmacology
Přispěvatelé: Wellcome Trust, Commission of the European Communities, Afd Pharmacology, Pharmacology
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Cell type
LUNG-DISEASES
Exosomes/pathology
lcsh:Medicine
Cellular Microenvironment/physiology
Disease
Review Article
Cell Communication
Biology
Research & Experimental Medicine
Exosomes
Exosome
OBSTRUCTIVE PULMONARY-DISEASE
DENDRITIC CELLS
General Biochemistry
Genetics and Molecular Biology
03 medical and health sciences
0302 clinical medicine
Immune system
AIRWAY SMOOTH-MUSCLE
microRNA
Animals
Humans
CELL-DERIVED EXOSOMES
IN-VIVO
Inflammation
Messenger RNA
Science & Technology
General Immunology and Microbiology
lcsh:R
EXTRACELLULAR VESICLES
General Medicine
Lipid signaling
Microvesicles
Asthma
3. Good health
Cell biology
030104 developmental biology
Cellular Microenvironment
Biotechnology & Applied Microbiology
Medicine
Research & Experimental
B-CELLS
Cell Communication/physiology
T-CELLS
MAST-CELLS
Life Sciences & Biomedicine
Asthma/pathology
030215 immunology
Inflammation/pathology
Zdroj: BioMed Research International, 2018. Hindawi Limited
BioMed Research International
BioMed Research International, Vol 2018 (2018)
ISSN: 2314-6133
DOI: 10.1155/2018/2862187
Popis: Exosomes are nanosized vesicles and have recently been recognized as important players in cell-to-cell communication. Exosomes contain different mediators such as proteins, nucleic acids (DNA, mRNA, miRNAs, and other ncRNAs), and lipid mediators and can shuttle their exosomal content to both neighboring and distal cells. Exosomes are very effective in orchestrating immune responses in the airways and all cell types can contribute to the systemic exosome pool. Intracellular communication between the broad range of cell types within the lung is crucial in disease emphasizing the importance of exosomes. In asthma, exosomes affect the inflammatory microenvironment which ultimately determines the development or alleviation of the pathological symptoms. Recent studies in this area have provided insight into the underlying mechanisms of disease and led to interest in using exosomes as potential novel therapeutic agents.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje