Eosinophilic esophagitis: Latest insights from diagnosis to therapy
| Autor: | Aurelio Mauro, Ekaterina Safroneeva, Edoardo Savarino, Roberto Penagini, Camillo Ribi, Carine Blanchard, Heather Dawson, Alfredo J. Lucendo, Alain M. Schoepfer |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Genetics and Molecular Biology (all)
medicine.medical_specialty Dysphagia Eosinophilic esophagitis Food allergy Guidelines Patient-reported outcomes Proton pump inhibitor-responsive esophageal eosinophilia Neuroscience (all) Biochemistry Genetics and Molecular Biology (all) History and Philosophy of Science Diagnostic tools Biochemistry General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Esophagus 0302 clinical medicine medicine Humans Eosinophilia Intensive care medicine Disease entity Esophageal disease General Neuroscience Proton Pump Inhibitors medicine.disease 3. Good health Natural history 030220 oncology & carcinogenesis Practice Guidelines as Topic 030211 gastroenterology & hepatology medicine.symptom Esophageal dysfunction |
| Popis: | Eosinophilic esophagitis (EoE) represents a chronic, local immune-mediated esophageal disease, characterized clinically by symptoms related to esophageal dysfunction and histologically by eosinophil-predominant inflammation. Other systemic and local causes of esophageal eosinophilia should be excluded. Clinical manifestations or pathologic data should not be interpreted in isolation. EoE was first described as a distinct disease entity in 1993. Most patients are diagnosed with underlying food allergies. The first diagnostic and therapeutic guidelines were published in 2007 with a first update in 2011. In 2017, new international guidelines were published based on the GRADE methodology. These guidelines provide, among many other topics, insights on the role of proton pump inhibitor-responsive esophageal eosinophilia. Over the last two decades, considerable progress was made by stakeholders regarding the understanding of EoE's pathogenesis, genetic background, natural history, allergy workup, standardization of assessment of disease activity, evaluation of minimally invasive diagnostic tools, and new therapeutic approaches. This brief review provides further insights into latest diagnostic and therapeutic advances. |
| Databáze: | OpenAIRE |
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