Legionella quinlivanii strain isolated from a human: A case report and whole genome sequencing analysis
| Autor: | Cindy Lalancette, Kathryn Bernard, Eric Fournier, Jacques Malo, Jean-Michel Leduc, Simon Lévesque, Sébastien P. Faucher, Joseph Saoud, Ana Luisa Pacheco, Christine Martineau |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
Whole genome sequencing 0303 health sciences Strain (chemistry) biology medicine.diagnostic_test 030306 microbiology biology.organism_classification 16S ribosomal RNA Microbiology 03 medical and health sciences Infectious Diseases Bronchoalveolar lavage Lavage bronchoalveolaire Legionella quinlivanii medicine Clinical Case Report 030304 developmental biology |
| Zdroj: | J Assoc Med Microbiol Infect Dis Can |
| Popis: | We describe a strain of Legionella quinlivanii isolated from a bronchoalveolar lavage specimen from an 83-year-old patient in the province of Québec. Identification was done using 16S rRNA sequencing. The strain could replicate efficiently in human THP-1 macrophages and maintained a low level of cytotoxicity. Upon analyzing the whole genome sequencing data, the icm/dot secretion system was present, but the strain lacked some effector genes known to express proteins toxic to cells. The pathogenicity of this Legionella species should be investigated further. |
| Databáze: | OpenAIRE |
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