Immunological activity of lipopolysaccharide ofHelicobacter pylorion human peripheral mononuclear blood cells in comparison to lipopolysaccharides of other intestinal bacteria
| Autor: | U. Knipp, R.J. Adamek, S. Birkholz, C. Nietzki, Wolfgang Opferkuch |
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| Rok vydání: | 1993 |
| Předmět: |
Lipopolysaccharides
Microbiology (medical) Lipopolysaccharide medicine.medical_treatment Immunology Microbiology Campylobacter jejuni Peripheral blood mononuclear cell Helicobacter Infections Structure-Activity Relationship chemistry.chemical_compound Escherichia coli medicine Humans Immunology and Allergy Interleukin 6 Helicobacter pylori biology Interleukin-6 Tumor Necrosis Factor-alpha Interleukin General Medicine bacterial infections and mycoses biology.organism_classification Intestines Infectious Diseases Cytokine chemistry Leukocytes Mononuclear biology.protein Tumor necrosis factor alpha Mitogens Interleukin-1 |
| Zdroj: | FEMS Immunology & Medical Microbiology. 6:317-324 |
| ISSN: | 1574-695X 0928-8244 |
| Popis: | Lipopolysaccharide of Helicobacter pylori was tested for its mitogenicity and for its ability to stimulate cytokine release in human peripheral blood mononuclear cells (PBMC) of healthy and H. pylori-infected blood donors. Mitogenicity in PBMC induced by H. pylori LPS was similar to that induced by Campylobacter jejuni lipopolysaccharide, but lower than that induced by Escherichia coli lipopolysaccharide in the H. pylori negative blood donor group. Furthermore, H. pylori LPS was able to induce tumour necrosis factor (TNF) interleukin 1 (IL-1) and interleukin 6 (IL-6) secretion of PBMC. Compared with the ability of C. jejuni and E. coli lipopolysaccharides to stimulate cytokine release, H. pylori lipopolysaccharide induced a significantly lower TNF and IL-1 secretion of PBMC than the other tested bacterial lipopolysaccharides. Similar amounts of IL-6 release were obtained by stimulation of PBMC with H. pylori and C. jejuni lipopolysaccharides, whereas a higher IL-6 release was measured by stimulation with E. coli lipopolysaccharide. The results of this study suggest that H. pylori lipopolysaccharide has a lower immunological activity than lipopolysaccharides of other intestinal bacteria. This is probably due to its unusual acylation and phosphorylation pattern of lipid A. |
| Databáze: | OpenAIRE |
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