Left ventricular vortex and intraventricular pressure difference in dogs under various loading conditions
| Autor: | Akiko Uemura, Ryou Tanaka, Mayumi Ifuku, Katsuhiro Matsuura, Kazumi Shimada, Kotomi Sato, Ken Takahashi, Seijirow Goya, Takeshi Iso, Kenjirou Shiraishi |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Materials science Physiology Aorta Thoracic 030204 cardiovascular system & hematology Ventricular Function Left 030218 nuclear medicine & medical imaging 03 medical and health sciences Dogs 0302 clinical medicine Physiology (medical) Internal medicine Ventricular relaxation Ventricular Pressure medicine Animals Heart Balloon Occlusion Myocardial Contraction Vortex Close relationship Intraventricular pressure Hemorheology Cardiology Female Cardiology and Cardiovascular Medicine Research Article |
| Zdroj: | American Journal of Physiology-Heart and Circulatory Physiology. 316:H882-H888 |
| ISSN: | 1522-1539 0363-6135 |
| DOI: | 10.1152/ajpheart.00686.2018 |
| Popis: | Restrictions on the conventional evaluation of diastolic function have been recognized, especially under various loading conditions. Recently, new noninvasive ventricular vortex indexes have been introduced and are expected to reflect the cardiac function. Physiologically, there is a hypothesis that the intraventricular pressure difference (IVPD) is related to the formation of vortexes. IVPD and vortex indexes were simultaneously measured, and the relationship between the two was investigated. To verify the possibility of diastolic vorticity as an index of diastolic relaxation, a correlation between diastolic vorticity and the load dependency of vorticity [time constant (τ)] was examined. Six healthy dogs were studied using transthoracic echocardiography, pressure, and a conductance catheter. Vorticity was analyzed using vector flow mapping (VFM). IVPD was determined using Euler’s equation with color M-mode Doppler images. Data were obtained at baseline, at balloon dilatation in the thoracic aorta to alter afterload, at hydroxyethyl starch infusion to alter preload, and at milrinone administration to alter ventricular relaxation. Peak vorticity at early diastole (E-Vor) and IVPD of the midventricle (MIVPD) decreased under pressure loading, were unchanged under volume loading, and increased during milrinone administration. In multivariate analysis, the independent predictors of τ were global longitudinal strain, strain rate at early diastole, and E-Vor. MIVPD was strongly correlated with E-Vor ( r = 0.84). VFM-derived peak E vorticity was strongly related to IVPD, especially MIVPD, under various loading conditions. Both of these novel indexes are promising as reliable indexes of ventricular relaxation, independent from preload. NEW & NOTEWORTHY We showed the close relationship of vortex and intraventricular pressure difference and showed that both of them can become new markers of the left ventricular relaxation property. Our present study creates a paradigm for future studies in the field of intraventircular flow physiology and clinical diastology. |
| Databáze: | OpenAIRE |
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