Hypoglycemic potential of herbal product dolabi compared with pioglitazone in streptozotocin-induced diabetic rats
| Autor: | Khalil Ur Rahman, Muhammad Iqbal Khan, Muhammad Idrees, Naeem Ullah Jan, Inayat U Rahman |
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| Rok vydání: | 2016 |
| Předmět: |
endocrine system diseases
business.industry General Medicine 030204 cardiovascular system & hematology Pharmacology medicine.disease Streptozotocin 03 medical and health sciences 0302 clinical medicine Complementary and alternative medicine Diabetes mellitus Medicine public health Medicine Pharmacology (medical) 030212 general & internal medicine business Pioglitazone medicine.drug |
| Zdroj: | Chinese Journal of Integrative Medicine. |
| ISSN: | 1993-0402 1672-0415 |
| DOI: | 10.1007/s11655-016-2583-1 |
| Popis: | To investigate and compare the hypoglycemic potential of commonly used polyherbal formulation dolabi with pioglitazone in streptozotocin-induced diabetic rats.A total of 24 adult male Wistar rats were randomized into diabetic control group, diabetic group receiving dolabi (17.6 mg kgCompared with baseline, the groups receiving dolabi (35.2 mg kgThese results showed sluggish hypoglycemic effects of dolabi at manufacturer's recommended doses. At a higher dose however, good glycemic control was achieved with dolabi and the results were comparable to pioglitazone. The shorter duration of study (4 weeks) might be the reason of poor glycemic control associated with dolabi at a normal dose. |
| Databáze: | OpenAIRE |
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