A toll-like receptor 2 genetic variant modulates occurrence of bacterial infections in patients with sickle cell disease
| Autor: | Itauá Leston-Araujo, Guilherme Henrique Hencklain Fonseca, Luciana Ribeiro Jarduli, Ibrahima Diagne, Renato Cunha, Yahia Benzerara, Ana Cristina Silva Pinto, Kelen C. R. Malmegrim, Annalisa Ruggeri, Ryad Tamouza, Sandra Fátima Menosi Gualandro, Vanderson Rocha, Robert Girot, Karina Tozatto-Maio, Fernanda Volt, Chantal Kenzey, Carla Luana Dinardo, Indou D Ly, Christina Mary Mariaselvam, Eliane Gluckman, Hanadi Elayoubi, Simone Kashima, Barbara Cappelli, Evandra Strazza Rodrigues, Belinda Pinto Simões |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Candidate gene Adolescent Genotype Single-nucleotide polymorphism Anemia Sickle Cell Disease Immunogenetics Young Adult 03 medical and health sciences 0302 clinical medicine Humans Medicine Genetic Predisposition to Disease Child Aged Toll-like receptor business.industry GENÓTIPOS Genetic Variation Bacterial Infections Hematology Odds ratio Middle Aged Toll-Like Receptor 2 TLR2 Child Preschool 030220 oncology & carcinogenesis Africa Immunology Female business Brazil 030215 immunology |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| Popis: | Despite adequate immunization and penicillin prophylaxis, bacterial infections remain a leading cause of morbidity and mortality in patients with sickle cell disease (SCD). Besides hyposplenism, inflammatory and genetic factors might modulate their susceptibility to bacterial infections. We performed a candidate gene association of single nucleotide polymorphisms (SNPs) located in Toll-like receptor (TLR) genes, encoding prominent molecules for innate immune responses, with the occurrence of bacterial infections in patients with SCD. A cohort followed in centres in Brazil, France and Senegal (n = 430) was divided in two groups: patients who presented at least one episode of bacterial infection (n = 235) and patients who never had bacterial infections (n = 195). There were no differences in gender or age distribution among the groups. The frequency of the TLR2 rs4696480 TA genotype was significantly lower in the infected group (50% vs. 67%, odds ratio [OR] = 0·50, 95% confidence interval [CI] 0·34-0·75, P |
| Databáze: | OpenAIRE |
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