Interactive association between dietary fat and sex on CDH13 cg02263260 methylation
| Autor: | Oswald Ndi Nfor, Bei-Hao Shiu, Ming-Chih Chou, Yung-Po Liaw, Wen-Yu Lu, Disline Manli Tantoh, Chi-Chou Huang |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male lcsh:Internal medicine lcsh:QH426-470 Fat intake Physiology medicine.disease_cause Genetics Medicine Humans Epigenetics lcsh:RC31-1245 Genetics (clinical) Dietary fat DNA methylation business.industry Methylation Middle Aged Cadherins Dietary Fats Confidence interval Human genetics lcsh:Genetics cg02263260 Cochran–Armitage test for trend Cadherin Female Sex business Carcinogenesis Research Article |
| Zdroj: | BMC Medical Genomics BMC Medical Genomics, Vol 14, Iss 1, Pp 1-9 (2021) |
| ISSN: | 1755-8794 |
| Popis: | Background DNA methylation of Cadherin 13 (CDH13), a tumor suppressor gene is associated with gene repression and carcinogenesis. We determined the relation of dietary fat and sex with CDH13 cg02263260 methylation in Taiwanese adults. Methods Data of 870 eligible participants (430 men and 440 women) between 30 and 70 years were obtained from the Taiwan Biobank (TWB) database. The association of dietary fat and sex with CDH13 cg02263260 methylation was determined using multiple linear regression. Results The association between sex and cg02263260 methylation was significant: beta-coefficient (β) = 0.00532; 95% confidence interval (CI) = 0.00195–0.00868. Moreover, the interaction between sex and dietary fat on cg02263260 methylation was significant (P-value = 0.0145). After stratification by sex, the association of dietary fat with cg02263260 methylation was significant only in women. Specifically, high dietary fat was positively associated with cg02263260 methylation in women (β = 0.00597; 95% CI = 0.00061–0.01133) and the test for trend was significant (P-value = 0.0283). Conclusion High fat intake was significantly associated with higher cg02263260 methylation in women and the test for trend was significant. These findings suggest that the association of fat intake and CDH13 cg02263260 might vary by sex and CDH13 cg02263260 methylation levels in women might increase as fat intake increases. |
| Databáze: | OpenAIRE |
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