Betaine supplementation lowers plasma homocysteine in healthy men and women
| Autor: | Martijn B. Katan, Gery R. Steenge, Petra Verhoef |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Methyltransferase Homocysteine cardiovascular-disease Medicine (miscellaneous) Blood Pressure vascular-disease Placebo Body Mass Index chemistry.chemical_compound Eating Betaine Folic Acid Reference Values Internal medicine medicine Ingestion Humans pyridoxine VLAG Global Nutrition methionine Wereldvoeding Nutrition and Dietetics Methionine biology Chemistry Area under the curve Fasting dose folic-acid methylenetetrahydrofolate reductase Lipids dietary betaine Diet Endocrinology risk factor Methylenetetrahydrofolate reductase Dietary Supplements biology.protein methyltransferase Female metabolism |
| Zdroj: | The Journal of Nutrition, 133(5), 1291-1295 The Journal of Nutrition 133 (2003) 5 |
| ISSN: | 0022-3166 |
| Popis: | Elevated levels of plasma total homocysteine are associated with a higher risk of cardiovascular disease. Betaine and 5-methyltetrahydrofolate can remethylate homocysteine into methionine via independent reactions. We determined the effect of daily betaine supplementation, compared with both folic acid and placebo, on plasma concentrations of total homocysteine after an overnight fast and after methionine loading in men and women with mildly elevated homocysteine. Groups of twelve subjects ingested 6 g betaine, 800 jig folic acid with 6 g placebo or 6 g placebo each day for 6 wk. A methionine-loading test (i.e., ingestion Of 100 mg L-methionine/kg body mass) was performed before and after 6 wk of supplementation. Fasting plasma homocysteine decreased by 1.8 mumol/L (95% confidence interval [CI]: -3.6, 0.0, P |
| Databáze: | OpenAIRE |
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