Early life predictors of midlife allostatic load: A prospective cohort study

Autor: Jolene Masters Pedersen, Dinne Skjærlund Christensen, Trine Flensborg-Madsen, Erik Lykke Mortensen, Åse Marie Hansen, Ellen Garde
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Gerontology
Male
Parents
Physiology
Maternal Health
Health Status
lcsh:Medicine
030204 cardiovascular system & hematology
Biochemistry
Pediatrics
Body Mass Index
Cohort Studies
Families
0302 clinical medicine
Pregnancy
Medicine and Health Sciences
Medicine
Birth Weight
Public and Occupational Health
030212 general & internal medicine
Prospective Studies
Prospective cohort study
lcsh:Science
Sex Characteristics
Multidisciplinary
Child Health
Allostasis
Obstetrics and Gynecology
Middle Aged
Allostatic load
Socioeconomic Aspects of Health
Physiological Parameters
Research Design
Cohort
Female
Behavioral and Social Aspects of Health
Psychosocial
Cohort study
Research Article
Birth weight
Mothers
Research and Analysis Methods
03 medical and health sciences
Humans
Socioeconomic status
business.industry
Body Weight
lcsh:R
Biology and Life Sciences
Infant
Correction
Health Status Disparities
Health Care
Social Class
People and Places
Women's Health
Population Groupings
lcsh:Q
business
Biomarkers
Zdroj: PLoS ONE, Vol 13, Iss 8, p e0202395 (2018)
PLoS ONE
Christensen, D S, Flensborg-Madsen, T, Garde, E, Hansen, Å M, Masters Pedersen, J & Mortensen, E L 2018, ' Early life predictors of midlife allostatic load : A prospective cohort study ', PLoS ONE, vol. 13, no. 8, e0202395 . https://doi.org/10.1371/journal.pone.0202395
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0202395
Popis: BACKGROUND: Allostatic load has been suggested as a pathway through which experiences become biologically embedded to influence health. Research on childhood predictors of allostatic load has focused on socioeconomic and psychosocial exposures, while few studies include prospective measures of biomedical exposures. Further, findings on sex differences in the association of childhood predictors with various health outcomes related to allostatic load are ambiguous.AIMS: To examine the influence of early life biomedical and social factors in the first year of life on midlife allostatic load, assessing potential sex differences.METHODS: This prospective cohort study includes early life information collected at birth and a one year examination for 1,648 members of the Copenhagen Perinatal Cohort who also participated in the Copenhagen Aging and Midlife Biobank study (aged 49-52 years, 56% women). Allostatic load based on 14 biomarkers was selected as a measure of midlife health status. Early life factors were categorized as predominantly biomedical or social, and their associations with midlife allostatic load were examined in domain-specific and combined sex-stratified multiple regression models.RESULTS: The biomedical factors model explained 6.6% of the variance in midlife allostatic load in men and 6.7% in women, while the social model explained 4.1% of the variance in men and 7.3% in women. For both sexes, parental socioeconomic position at one year and maternal BMI significantly predicted midlife allostatic load in a model containing all early life factors. For women, additional significant predictors were complications at birth, birth weight and not living with parents at one year.CONCLUSION: The results confirm an association of lower childhood socioeconomic position with higher adult allostatic load while demonstrating the importance of other prenatal and early life exposures and highlighting potential sex differences.
Databáze: OpenAIRE
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