Concentration-response curves for ethylene-oxide-induced heritable translocations and dominant lethal mutations
| Autor: | W. M. Generoso, K. T. Cain, C. V. Cornett, N. L. A. Cacheiro, L. A. Hughes, R. J. Albertini, D. A. Casciano |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Ethylene Oxide
Male Epidemiology Ratón Health Toxicology and Mutagenesis Period (gene) Chromosomal translocation Biology medicine.disease_cause Translocation Genetic chemistry.chemical_compound Clastogen Mice Administration Inhalation medicine Animals Genetics (clinical) Genetics Mutation Mice Inbred C3H Ethylene oxide Concentration Response Inhalation Dose-Response Relationship Drug Incidence Molecular biology chemistry Mutagens |
| Zdroj: | Environmental and molecular mutagenesis. 16(2) |
| ISSN: | 0893-6692 |
| Popis: | Male mice were subjected to repeated inhalation exposures to different concentrations (165, 204, 250, or 300 ppm) of ethylene oxide (EtO) during an 8.5-week period. Transmitted clastogenic effects of these exposures were measured in terms of induction of dominant lethal mutations and heritable translocations. The concentration-response curves for both endpoints are not linear but are markedly concave upward. Significant increases in dominant lethals were detected at all concentrations, except the lowest one. In comparison, the incidences of heritable translocations were significantly increased at all concentrations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text