High titer of anti-citrullinated peptide antibody is a risk factor for severe carotid atherosclerotic plaque in patients with rheumatoid arthritis: the TOMORROW study

Autor: Kenji Mamoto, Tadashi Okano, Shinji Takahashi, Masahiro Tada, Tatsuya Koike, Yoshiki Matsumura, Kenichi Sugioka, Shigeyuki Wakitani, Kentaro Inui, Hiroaki Nakamura, Yuko Sugioka
Rok vydání: 2017
Předmět:
Adult
Carotid Artery Diseases
Male
medicine.medical_specialty
Pathology
030204 cardiovascular system & hematology
Logistic regression
Carotid Intima-Media Thickness
Severity of Illness Index
Gastroenterology
Anti-Citrullinated Protein Antibodies
Arthritis
Rheumatoid
Young Adult
03 medical and health sciences
0302 clinical medicine
Japan
Rheumatology
Risk Factors
Internal medicine
Odds Ratio
Prevalence
medicine
Humans
Prospective Studies
Risk factor
Aged
Aged
80 and over
030203 arthritis & rheumatology
Chi-Square Distribution
biology
business.industry
Antibody titer
Odds ratio
Middle Aged
medicine.disease
Plaque
Atherosclerotic
Confidence interval
Titer
Carotid Arteries
Cross-Sectional Studies
Logistic Models
Case-Control Studies
Rheumatoid arthritis
Linear Models
biology.protein
Female
Antibody
business
Biomarkers
Zdroj: International Journal of Rheumatic Diseases. 20:949-959
ISSN: 1756-1841
DOI: 10.1111/1756-185x.13106
Popis: Aim Cardiovascular disease is one of the complications of rheumatoid arthritis (RA). We researched the morbidity and severity of existing carotid atherosclerosis plaque and associated risk factors in patients with RA. Method This study included 413 participants, including 208 patients with RA and 205 age- and sex-matched healthy volunteers. Carotid ultrasound, clinical data collection and assessment of cardiovascular risk factors were performed. Atherosclerotic plaque was defined as an intima-media thickness ≥ 1.1 mm. Severity of plaque was assessed by plaque score, defined as the sum of the maximal thickness of all plaques in bilateral carotid arteries. Results Data were analyzed from 200 patients with RA and 202 controls. Carotid plaque was observed more frequently in patients with RA than controls (47.0 vs. 36.1%, P = 0.027). Moreover, plaque score was significantly higher in RA patients (P = 0.032). In logistic regression analysis, RA represented an independent risk factor for the presence of plaque (adjusted odds ratio, 1.68; 95% confidence interval, 1.03–2.74). Comparing RA patients with and without plaque, anti-cyclic citrullinated peptide (anti-CCP) antibodies titer was significantly higher in patients with plaque (315.8 ± 454.1 U/mL) than in patients without (165.7 ± 281.1 U/mL; P = 0.005). Moreover, multiple linear regression analysis clarified that anti-CCP antibody titer was associated with plaque score in patients with RA. Conclusion High prevalence of any carotid plaques and severe carotid plaques were more frequent in patients with RA. High titer of anti-CCP antibodies represented a risk factor for severe carotid atherosclerotic plaque in patients with RA.
Databáze: OpenAIRE
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