Serum lipid concentrations in subjects with phenylketonuria and their families
| Autor: | Steve A. Benford, Terry J. DeClue, James Davis, Dawn M. Schocken, Ruth Kangas |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Calorie Adolescent Phenylketonurias Offspring Saturated fat Population Diet Records Diet Surveys Cholesterol Dietary chemistry.chemical_compound Internal medicine medicine Dietary Carbohydrates Humans Family education Child Triglycerides education.field_of_study business.industry Cholesterol nutritional and metabolic diseases Infant Dietary Fats Endocrinology chemistry Child Preschool Pediatrics Perinatology and Child Health lipids (amino acids peptides and proteins) Female Dietary Proteins business Energy Intake Lipoprotein |
| Zdroj: | American journal of diseases of children (1960). 145(11) |
| ISSN: | 0002-922X |
| Popis: | • To determine if subjects with phenylketonuria receiving diets significantly lower in cholesterol and saturated fat had serum lipid concentrations different from those of their family members, we measured serum concentrations of total cholesterol, high-density lipoprotein cholesterol, and total triglycerides in the probands with phenylketonuria, their parents, and their siblings. Eleven adults (seven women and four men) and 16 children (eight girls and eight boys) were studied. Ten subjects (four girls and six boys) had phenylketonuria. Subjects with phenylketonuria consumed less cholesterol (0.02 vs 0.41 mmol/d ) and fat (median, 21% vs 39.5% of total calories), and their diets had a higher ratio of polyunsaturated to saturated fatty acids (median, 2.0 vs 0.2) than did their siblings without phenylketonuria. The diet of the parents was similar to that of their offspring without phenylketonuria. No differences were noted between the subjects with phenylketonuria (consuming a diet lower in saturated fat and cholesterol) and their siblings without phenylketonuria in serum concentrations of total cholesterol (median, 3.34 vs 3.07 mmol/L); high-density lipoprotein cholesterol (median, 1.44 vs 1.37 mmol/L); low-density lipoprotein cholesterol (median, 1.44 vs 1.09 mmol/L); or triglycerides (median, 0.89 vs 0.54 mmol/L). We conclude that previously reported lipoprotein abnormalities noted between unrelated subjects with and without phenylketonuria may not be due to differences in dietary intake, but rather due to a (genetic) predisposition of the population with phenylketonuria toward lower serum lipid concentrations. ( AJDC. 1991;145:1266-1268) |
| Databáze: | OpenAIRE |
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