Complete lymph node dissection or observation in melanoma patients with multiple positive sentinel lymph nodes: A single-center retrospective analysis
| Autor: | Jana Knuever, Oana-Diana Persa, Max Schlaak, Cornelia Mauch |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Skin Neoplasms Sentinel lymph node Dermatology Single Center 03 medical and health sciences 0302 clinical medicine medicine Humans 030212 general & internal medicine Progression-free survival Melanoma Lymph node Aged Retrospective Studies Sentinel Lymph Node Biopsy business.industry Micrometastasis General Medicine Middle Aged medicine.disease Survival Analysis Progression-Free Survival Dissection Treatment Outcome medicine.anatomical_structure Lymphatic Metastasis 030220 oncology & carcinogenesis Lymph Node Excision Female Radiology Lymph Neoplasm Recurrence Local Sentinel Lymph Node business Follow-Up Studies |
| Zdroj: | The Journal of Dermatology. 45:1191-1194 |
| ISSN: | 0385-2407 |
| Popis: | Although the role of sentinel lymph node biopsy (SLNB) as a prognostic factor is well established, its consequences for therapy are controversial. The aim of this study was to analyze if complete lymph node dissection (CLND) in patients with more than one positive sentinel lymph node (SLN) significantly improves melanoma-specific survival (MSS) and progression-free survival (PFS). Medical records of patients who underwent SLNB between 2001 and 2016 at the University Hospital of Cologne were reviewed, and patients with positive SLN were identified. Patient and tumor characteristics, patterns of recurrence, progression-free and melanoma-specific survival were analyzed. Seventy-eight patients with multiple positive and 197 patients with one positive SLN were included in this study. Patients with multiple positive SLN had significantly more positive non-SLN compared with patients with only one positive SLN (26.9% vs 8.6%, P = 0.01). However, in the subgroup of patients with multiple positive SLN, CLND did not significantly improve MSS (mean MSS 95 vs 75 months, P = 0.5) and PFS (mean PFS 59 vs 68 months P = 0.167). CLND did not result in a significant improvement in PFS and MSS in patients with multiple positive SLN. |
| Databáze: | OpenAIRE |
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