| Autor: |
Julien Guiot, Monique Henket, Anne-Noëlle Frix, Fanny Gester, Marie Thys, Laurie Giltay, Colin Desir, Catherine Moermans, Makon-Sébastien Njock, Paul Meunier, Jean-Louis Corhay, Renaud Louis |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Respiratory research. 23(1) |
| ISSN: |
1465-993X |
| Popis: |
Background Patients suffering from combined obstructive and interstitial lung disease (O-ILD) represent a pathological entity which still has to be well clinically described. The aim of this descriptive and explorative study was to describe the phenotype and functional characteristics of a cohort of patients suffering from functional obstruction in a population of ILD patients in order to raise the need of dedicated prospective observational studies and the evaluation of the impact of anti-fibrotic therapies. Methods The current authors conducted a retrospective study including 557 ILD patients, with either obstructive (O-ILD, n = 82) or non-obstructive (non O-ILD, n = 475) pattern. Patients included were mainly males (54%) with a mean age of 62 years. Results Patients with O-ILD exhibited a characteristic functional profile with reduced percent predicted forced expired volume in 1 s (FEV1) [65% (53–77) vs 83% (71–96), p Conclusions The authors individualized a specific functional-based pattern of ILD patients with obstructive lung disease, who are at risk of increased mortality and rapid DLCO decline over time. As classically those patients are excluded from clinical trials, a dedicated prospective study would be of interest in order to define more precisely treatment response of those patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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