High frequency of autoimmunization among transfusion-dependent Tunisian thalassaemia patients
| Autor: | F. Mellouli, M. Ouderni, M. Bejaoui, H. Hmida, M. Mezri, S. Hmida, N. Guirat-Dhouib, H. Kaabi, Béchir Zouari |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Erythrocytes Tunisia Adolescent Platelet Transfusion Blood exposure Coombs test Antigen Isoantibodies Positive Coombs Test medicine Humans In patient Child medicine.diagnostic_test business.industry Transfusion Reaction Mean age Hematology Child Preschool Transfusion dependence Immunology Thalassemia Female Complication business |
| Zdroj: | Transfusion and Apheresis Science. 45:199-202 |
| ISSN: | 1473-0502 |
| DOI: | 10.1016/j.transci.2011.08.003 |
| Popis: | Background Limited data are available on the frequency of RBC alloimmunization and autoimmunization in transfusion-dependant Tunisian β thalassaemia patients. Materials and methods We analyzed the clinical and transfusion records of 130 patients (57 females and 73 males; mean age 119 months; range 12–11 months) with β thalassaemia major and who had regular blood transfusions for periods ranging from 12 to 311 months. Results Of the 130 patients, ten (7.7%) developed RBC alloantibodies. The most common alloantibodies were directed against antigens in the Rh systems. Erythrocyte-autoantibodies as determined by a positive direct antiglobulin Coombs test, developed in 52(40%) patients with and without underlying RBC alloantibodies, thereby causing autoimmune haemolytic anaemia in eleven patients (21%). Conclusions Autoimmunization to erythrocyte antigens is a frequent complication in patients with β thalassaemia major. Several factors might have contributed to the high autoimmunization rate observed in this study, including non phenotypic blood exposure and alloantibody formation prior to positive Coombs test. |
| Databáze: | OpenAIRE |
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