Duodenal Aspirates for Small Intestine Bacterial Overgrowth: Yield, PPIs, and Outcomes after Treatment at a Tertiary Academic Medical Center
| Autor: | Michael D. Crowell, Laura Koepke, M. Edwyn Harrison, Francisco C. Ramirez, Molly Disbrow, Allon Kahn, Lucinda A. Harris, Diana L. Franco |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Pathology Hepatology Article Subject medicine.drug_class business.industry Medical record Antibiotics Gastroenterology Proton-pump inhibitor Retrospective cohort study medicine.disease Small intestine medicine.anatomical_structure Internal medicine Small intestinal bacterial overgrowth medicine Duodenum lcsh:Diseases of the digestive system. Gastroenterology lcsh:RC799-869 business After treatment Research Article |
| Zdroj: | Gastroenterology Research and Practice, Vol 2015 (2015) Gastroenterology Research and Practice |
| ISSN: | 1687-6121 |
| DOI: | 10.1155/2015/971582 |
| Popis: | Duodenal aspirates are not commonly collected, but they can be easily used in detection of small intestinal bacterial overgrowth (SIBO). Proton pump inhibitor (PPI) use has been proposed to contribute to the development of SIBO. We aimed to determine the yield of SIBO-positive cultures detected in duodenal aspirates, the relationship between SIBO and PPI use, and the clinical outcomes of patients identified by this method. In a retrospective study, we analyzed electronic medical records from 1263 consecutive patients undergoing upper endoscopy at a tertiary medical center. Aspirates were collected thought out the third and fourth portions of the duodenum, and cultures were considered to be positive for SIBO if they produced more than 100,000 cfu/mL. Culture analysis of duodenal aspirates identified SIBO in one-third of patients. A significantly higher percentage of patients with SIBO use PPIs than patients without SIBO, indicating a possible association. Similar proportions of patients with SIBO improved whether or not they received antibiotic treatment, calling into question the use of this expensive therapy for this disorder. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|