Effects of β-Diethylaminoethyl Diphenylpropylacetate Hydrochloride on Three Convulsants and on Propallylonal
| Autor: | Gale E. Demaree, Harald G.O. Holck, Hideko Katayama Kaji |
|---|---|
| Rok vydání: | 1962 |
| Předmět: |
Hydrochloride
medicine.drug_class musculoskeletal neural and ocular physiology Pharmaceutical Science Convulsants Pharmacology Barbital Hypnotic chemistry.chemical_compound Nikethamide nervous system chemistry Barbiturates Toxicity medicine Humans Hypnotics and Sedatives Central Nervous System Stimulants Pentylenetetrazol medicine.drug Picrotoxin |
| Zdroj: | Journal of Pharmaceutical Sciences. 51:739-742 |
| ISSN: | 0022-3549 |
| DOI: | 10.1002/jps.2600510808 |
| Popis: | β-Diethylaminoethyl diphenylpropylacetate hydrochloride (SKF 525-A) increased the LD50s of nikethamide, pentylenetetrazol, and picrotoxin in albino mice when given intraperitoneally 1 hour earlier. The maximum action of picrotoxin in mice subcutaneously pretreated with SKF 525-A developed in about 4 hours; action was still marked at 8, but largely absent at 16 hours. SKF 525-A induced full effect when given intraperitoneally immediately before picrotoxin. It also markedly increased the potency of picrotoxin in normal and in barbitalized rats, using a multiple injection technique. However, SKF 525-A did not influence the toxicity of pentylenetetrazol in normal or barbitalized rats employing this technique. Barbital greatly increased the LD50s of pentylenetetrazol and picrotoxin in rats, as shown by the multiple injection method. SKF 525-A markedly prolonged the hypnotic effect of propallylonal without increasing the number of delayed deaths. Its use is recommended for biotransformation studies of the four substances used. |
| Databáze: | OpenAIRE |
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