Differential expression of Epstein-Barr virus-encoded RNA and several tumor-related genes in various types of nasopharyngeal epithelial lesions and nasopharyngeal carcinoma using tissue microarray analysis
| Autor: | Qiuhong Zhang, Yanhong Zhou, Shourong Shen, Jian Ma, Yang-Jue Ou, Xiaoling Li, Ming Zhou, Chen Tan, Bingyi Xiao, Hou-De Zhuo, Guiyuan Li, Wei Xiong, Wenling Zhang, Songqing Fan, Jie Zhou, Songquing Fan |
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| Rok vydání: | 2005 |
| Předmět: |
Pathology
medicine.medical_specialty In situ hybridization Biology Adenocarcinoma medicine.disease_cause Pathology and Forensic Medicine medicine Biomarkers Tumor Gammaherpesvirinae Humans In Situ Hybridization Tissue microarray Hyperplasia Epithelial Cells Nasopharyngeal Neoplasms medicine.disease biology.organism_classification Epstein–Barr virus Immunohistochemistry Neoplasm Proteins Nasopharyngeal carcinoma Tissue Array Analysis Cancer research RNA Viral Carcinogenesis |
| Zdroj: | Human pathology. 37(5) |
| ISSN: | 0046-8177 |
| Popis: | Studies have revealed that Epstein-Barr virus (EBV) infection, genetic aberration, and environmental factors are of importance in the development of nasopharyngeal carcinoma (NPC), although the definite mechanism remains to be fully elucidated. The aim of our study is to investigate using tissue microarray analysis whether differential expression of EBV-encoded small RNA-1 (EBER-1) and several tumor-related genes were associated with NPC carcinogenesis. Immunohistochemistry and in situ hybridization were performed on tissue microarrays containing 148 NPCs and 164 noncancerous nasopharyngeal epithelia (NPE) with different morphologic features. We found that overexpressions of EBER-1 hybridization signals, p53, p21ras, and bcl-2 proteins and loss expressions of p16 and p27 proteins were significantly increased in NPC tissues compared with normal NPE and hyperplastic NPE (P |
| Databáze: | OpenAIRE |
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