Genetic Variation in P2rx7 and Pain Tolerance
| Autor: | Eija Kalso, Tom Wilsgaard, Bendik S. Winsvold, Oleg Kambur, Mari A. Kaunisto, Audun Stubhaug, Christopher Sivert Nielsen, John-Anker Zwart |
|---|---|
| Přispěvatelé: | Department of Pharmacology, Medicum, Faculty of Medicine, University of Helsinki, Institute for Molecular Medicine Finland, Helsinki Institute of Life Science HiLIFE, Eija Kalso / Principal Investigator, Department of Diagnostics and Therapeutics, Clinicum, Anestesiologian yksikkö, HUS Perioperative, Intensive Care and Pain Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Oncology Male Pain tolerance DNA Mutational Analysis ION-CHANNEL SUSCEPTIBILITY VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Nevrologi: 752 Cohort Studies Experimental pain 0302 clinical medicine P2X7 RECEPTOR Young adult POPULATION Pain Measurement education.field_of_study NEUROPATHIC PAIN Chronic pain Cold pressor test P2X(7) RECEPTOR ASSOCIATION Middle Aged Cold-pressor test Neurology Neuropathic pain Female SENSITIVITY P2X7 Research Paper Adult Pain Threshold medicine.medical_specialty GAIN-OF-FUNCTION Adolescent Genotype Population Pain SNP Community Health Planning 03 medical and health sciences Young Adult Breast cancer Sex Factors Internal medicine medicine Humans Polymorphism education Aged business.industry Genetic Variation P2RX7 medicine.disease 3126 Surgery anesthesiology intensive care radiology 030104 developmental biology Anesthesiology and Pain Medicine Cross-Sectional Studies VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Neurology: 752 Neurology (clinical) Receptors Purinergic P2X7 business 030217 neurology & neurosurgery |
| Zdroj: | Pain |
| ISSN: | 0304-3959 |
| Popis: | Supplemental Digital Content is Available in the Text. Variation in the P2RX7-gene, particularly single-nucleotide polymorphism rs7958311, may modulate human pain sensitivity in experimental and clinical pain phenotypes. P2X7 is a nonselective cation channel activated by extracellular ATP. P2X7 activation contributes to the proinflammatory response to injury or bacterial invasion and mediates apoptosis. Recently, P2X7 function has been linked to chronic inflammatory and neuropathic pain. P2X7 may contribute to pain modulation both by effects on peripheral tissue injury underlying clinical pain states, and through alterations in central nervous system processing, as suggested by animal models. To further test its role in pain sensitivity, we examined whether variation within the P2RX7 gene, which encodes the P2X7 receptor, was associated with experimentally induced pain in human patients. Experimental pain was assessed in Tromsø 6, a longitudinal and cross-sectional population-based study (N = 3016), and the BrePainGen cohort, consisting of patients who underwent breast cancer surgery (N = 831). For both cohorts, experimental pain intensity and tolerance were assessed with the cold-pressor test. In addition, multisite chronic pain was assessed in Tromsø 6 and pain intensity 1 week after surgery was assessed in BrePainGen. We tested whether the single-nucleotide polymorphism rs7958311, previously implicated in clinical pain, was associated with experimental and clinical pain phenotypes. In addition, we examined effects of single-nucleotide polymorphisms rs208294 and rs208296, for which previous results have been equivocal. Rs7958311 was associated with experimental pain intensity in the meta-analysis of both cohorts. Significant associations were also found for multisite pain and postoperative pain. Our results strengthen the existing evidence and suggest that P2X7 and genetic variation in the P2RX7-gene may be involved in the modulation of human pain sensitivity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|