Investigations of 2 cases of diphtheria-like illness due to toxigenic Corynebacterium ulcerans
| Autor: | Pamela K. Cassiday, John S. Moran, Anne Golaz, Timothy F. Jones, Melinda Wharton, Tejpratap S P Tiwari, Diana T. Yu, Tanja Popovic, Kristen R. Ehresmann, Hal E. Hill, Lucia C. Pawloski |
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| Rok vydání: | 2008 |
| Předmět: |
Microbiology (medical)
Male Diphtheria vaccine Diphtheria Toxoid Corynebacterium Erythromycin complex mixtures Microbiology Diagnosis Differential Fatal Outcome Corynebacterium ulcerans Drug Resistance Multiple Bacterial Medicine Humans Aged Diphtheria toxin biology Corynebacterium Infections business.industry Diphtheria Clindamycin biology.organism_classification medicine.disease Virology United States Diphtheria Antitoxin Vaccination Infectious Diseases Female business medicine.drug |
| Zdroj: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 46(3) |
| ISSN: | 1537-6591 |
| Popis: | Background. We present 2 case reports in the United States and investigations of diphtheria-like illness caused by toxigenic Corynebacterium ulcerans. A fatal case occurred in a 75-year-old male Washington resident who was treated with clindamycin but did not receive equine diphtheria antitoxin. A second, nonfatal case occurred in a 66-year-old female Tennessee resident who received erythromycin and diphtheria antitoxin. Methods. Both case patients and close human and animal contacts were investigated by their respective state health departments. Results. C. ulcerans isolated from the patient who died was resistant to erythromycin and clindamycin. For both isolates, conventional polymerase chain reaction results were positive for A and B subunits of diphtheria toxin gene tox, and modified Elek tests confirmed toxin production. The source of infection remained undetermined for both cases. Neither patient was up-to-date with diphtheria toxoid vaccination. Conclusion. These case reports highlight the importance of early treatment with diphtheria antitoxin, the selection of effective antimicrobial agents, and prevention through up-to-date vaccination. |
| Databáze: | OpenAIRE |
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