Tissue-mimicking phantoms for photoacoustic and ultrasonic imaging
| Autor: | Stanislav Emelianov, Jason R. Cook, Richard R. Bouchard |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Absorption (acoustics)
Materials science 02 engineering and technology 01 natural sciences Imaging phantom Light scattering 010309 optics ocis:(290.5820) Scattering measurements Optics ocis:(170.7170) Ultrasound 0103 physical sciences Calibration Validation and Phantom Studies ocis:(110.3000) Image quality assessment Scattering business.industry Ultrasound 021001 nanoscience & nanotechnology ocis:(160.4760) Optical properties Atomic and Molecular Physics and Optics ocis:(170.5120) Photoacoustic imaging Attenuation coefficient Ultrasonic sensor 0210 nano-technology business Acoustic attenuation Biotechnology |
| Zdroj: | Biomedical Optics Express |
| ISSN: | 2156-7085 |
| DOI: | 10.1364/boe.2.003193 |
| Popis: | In both photoacoustic (PA) and ultrasonic (US) imaging, overall image quality is influenced by the optical and acoustical properties of the medium. Consequently, with the increased use of combined PA and US (PAUS) imaging in preclinical and clinical applications, the ability to provide phantoms that are capable of mimicking desired properties of soft tissues is critical. To this end, gelatin-based phantoms were constructed with various additives to provide realistic acoustic and optical properties. Forty-micron, spherical silica particles were used to induce acoustic scattering, Intralipid(®) 20% IV fat emulsion was employed to enhance optical scattering and ultrasonic attenuation, while India Ink, Direct Red 81, and Evans blue dyes were utilized to achieve optical absorption typical of soft tissues. The following parameters were then measured in each phantom formulation: speed of sound, acoustic attenuation (from 6 to 22 MHz), acoustic backscatter coefficient (from 6 to 22 MHz), optical absorption (from 400 nm to 1300 nm), and optical scattering (from 400 nm to 1300 nm). Results from these measurements were then compared to similar measurements, which are offered by the literature, for various soft tissue types. Based on these comparisons, it was shown that a reasonably accurate tissue-mimicking phantom could be constructed using a gelatin base with the aforementioned additives. Thus, it is possible to construct a phantom that mimics specific tissue acoustical and/or optical properties for the purpose of PAUS imaging studies. |
| Databáze: | OpenAIRE |
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