Therapeutic effects of orally administered CJLP55 for atopic dermatitis via the regulation of immune response
| Autor: | Eon Sub Park, Bongjoon Kim, Soo Jeong Kim, Hee-Yoon Ahn, Byoung Seok Moon, Kyeong Eun Hyung, Ye Won Jang, Da Kyoung Lee, So-Young Park, Kee Hyeob Hyun, Kwang Woo Hwang, Uy Dong Sohn |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Axillary lymph nodes Physiology Population Dermatitis Immunoglobulin E Atopic 03 medical and health sciences 0302 clinical medicine Immune system Medicine education Lymph node Pharmacology House dust mite education.field_of_study Dermatophagoides farinae biology business.industry Probiotics Interleukin Atopic dermatitis medicine.disease biology.organism_classification Lactobacillus Th2 cells 030104 developmental biology medicine.anatomical_structure 030228 respiratory system Immunology biology.protein Original Article business |
| Zdroj: | The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology |
| ISSN: | 2093-3827 1226-4512 |
| Popis: | Atopic dermatitis (AD) is an inflammatory skin condition accompanied by symptoms such as edema and hemorrhage. Kimchi is a traditional fermented Korean dish consisting of various probiotics. In this study, the therapeutic effect of Lactobacillus plantarum CJLP55 isolated from Kimchi was studied in AD-induced mice. Orally administered Lactobacillus strain, CJLP55, suppressed AD symptoms and high serum IgE levels. CJLP55 administration reduced the thickness of the epidermis, infiltration of mast cells and eosinophils into the skin lesion, enlargement of axillary lymph nodes, and increase in cell population in axillary lymph nodes. CJLP55 treatment decreased the production of type 2 cytokines, such as interleukin (IL)-4, IL-5, IL-10, IL-12, interferon (IFN)-γ, and IL-6,which were stimulated by house dust mite extracts, in the axillary lymph node cells. Orally administered CJLP55 exhibited a therapeutic effect on house dust mite-induced AD in NC/Nga mice after onset of the disease by altering immune cell activation. The Lactobacillus strain, CJLP55, isolated from Kimchi, suppressed AD. Our results suggest its possible use as a potential candidate for management of AD. |
| Databáze: | OpenAIRE |
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