Age-related memory decline is associated with vascular and microglial degeneration in aged rats
Autor: | Tamar Kadar, Rong Zhang, Jian Guan, Ernest Sirimanne, Alastair K. H. MacGibbon |
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Rok vydání: | 2012 |
Předmět: |
Male
medicine.medical_specialty Aging Tyrosine 3-Monooxygenase Morris water navigation task Nerve Tissue Proteins Normal aging Nitric Oxide Synthase Type I Choline O-Acetyltransferase Behavioral Neuroscience chemistry.chemical_compound Dopamine Internal medicine Immunochemistry Glial Fibrillary Acidic Protein medicine Memory impairment Animals Vascular Diseases Young adult Maze Learning Swimming Analysis of Variance Memory Disorders Vascular Endothelial Growth Factors Neurodegeneration Age Factors Brain medicine.disease Rats Vascular endothelial growth factor Disease Models Animal Endocrinology nervous system chemistry Antigens Surface Microglia Psychology Neuroscience Locomotion medicine.drug |
Zdroj: | Behavioural brain research. 235(2) |
ISSN: | 1872-7549 |
Popis: | The hippocampus processes memory is an early target of aging-related biological and structural lesions, leading to memory decline. With absent neurodegeneration in the hippocampus, which identified in rodent model of normal aging the pathology underlying age-related memory impairment is not complete. The effective glial–vascular networks are the key for maintaining neuronal functions. The changes of glial cells and cerebral capillaries with age may contribute to memory decline. Thus we examined age associated changes in neurons, glial phenotypes and microvasculature in the hippocampus of aged rats with memory decline. Young adult (6 months) and aged (35 months) male rats (Fisher/Norway-Brown) were used. To evaluate memory, four days of acquisition phase of Morris water maze tasks were carried out in both age groups and followed by a probe trial 2 h after the acquisition. The brains were then collected for analysis using immunochemistry. The aged rats showed a delayed latency (p |
Databáze: | OpenAIRE |
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