A moldable sustained release bupivacaine formulation for tailored treatment of postoperative dental pain
| Autor: | James M. Harrington, Leah M. Johnson, Ginger Denison Rothrock, Sarah D. Shepherd, Andrea G. Nackley, Laura G. Haines, Sandra C. O’Buckley |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Molar Drug Compounding medicine.medical_treatment Analgesic lcsh:Medicine 02 engineering and technology Article 03 medical and health sciences chemistry.chemical_compound Drug Delivery Systems 0302 clinical medicine Polylactic Acid-Polyglycolic Acid Copolymer medicine Animals Anesthetics Local lcsh:Science Dialysis Hemostat Bupivacaine Analgesics Pain Postoperative Multidisciplinary business.industry lcsh:R 021001 nanoscience & nanotechnology Microspheres Rats PLGA chemistry Hyperalgesia Delayed-Action Preparations Anesthesia Tooth Extraction Anesthetic Female lcsh:Q medicine.symptom 0210 nano-technology business Polyglycolic Acid 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018) Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-018-29696-w |
| Popis: | A moldable and biodegradable dental material was designed for customized placement and sustained delivery of bupivacaine (BP) within an extraction cavity. Microparticles comprising poly(lactic-co-glycolic acid) (PLGA) containing BP were generated via solvent-evaporation and combined with absorbable hemostat Gelfoam®. Kinetics of drug release were evaluated by in vitro dialysis assays, showing higher release within the first 24 hours, with subsequent tapering of release kinetics. Formulations of Gelfoam® and BP-PLGA microparticles (GelBP), with three targeted dosing profiles (0.25, 0.5, and 1 mg/kg/day), were evaluated alongside acute subcutaneous BP injections (2 mg/kg) to determine analgesic efficacy in a rat model of tooth extraction pain. Molar extraction resulted in mechanical and thermal cold hyperalgesia in male and female rats. GelBP outperformed acute BP in blocking post-surgical dental pain, with the 0.25 mg/kg GelBP dose preventing hypersensitivity to mechanical (p |
| Databáze: | OpenAIRE |
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