| Autor: |
David L. Cain, Niall A. Anderson, David B. Cordes, Alexandra M. Z. Slawin, Allan J. B. Watson |
| Přispěvatelé: |
University of St Andrews. School of Chemistry, University of St Andrews. EaSTCHEM, University of St Andrews. Sir James Mackenzie Institute for Early Diagnosis |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Popis: |
Funding: D.L.C. thanks EPSRC and GSK for a Ph.D. studentship. A concise strategy for the total synthesis of several Aspidosperma alkaloids is reported. A Suzuki–Miyaura cross-coupling provides access to a 2-vinyl indole that undergoes a Diels–Alder cascade reaction with butyn-2-one to deliver a pyrroloindoline intermediate. This undergoes cascade amidation, reduction, skeletal rearrangement, and intramolecular Michael addition to provide a common intermediate containing the full framework of the Aspidosperma alkaloids. The utility of this intermediate is shown in the synthesis of four different natural products. Publisher PDF |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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