Magnesium Sulfate Enables Patient Immobilization during Moderate Block and Ameliorates the Pain and Analgesic Requirements in Spine Surgery, Which Can Not Be Achieved with Opioid-Only Protocol: A Randomized Double-Blind Placebo-Controlled Study

Autor:	Hye-Min Sohn, Yu-Kyung Bae, Bo-Young Kim, Won-Seok Seo, Young-Tae Jeon
Rok vydání:	2021
Předmět:	Magnesium business.industry Opioid consumption Analgesic Placebo-controlled study chemistry.chemical_element General Medicine Article spine surgery Spine surgery magnesium sulfate chemistry Opioid Anesthesia opioid consumption medicine Medicine neuromuscular blocking drugs Rocuronium intraoperative neurophysiological monitoring business postoperative pain Intraoperative neurophysiological monitoring medicine.drug
Zdroj:	Journal of Clinical Medicine Volume 10 Issue 19 Journal of Clinical Medicine, Vol 10, Iss 4289, p 4289 (2021)
ISSN:	2077-0383
Popis:	Spine surgery is painful despite the balanced techniques including intraoperative and postoperative opioids use. We investigated the effect of intraoperative magnesium sulfate (MgSO4) on acute pain intensity, analgesic consumption and intraoperative neurophysiological monitoring (IOM) during spine surgery. Seventy-two patients were randomly allocated to two groups: the Mg group or the control group. The pain intensity was significantly alleviated in the Mg group at 24 h (3.2 ± 1.7 vs. 4.4 ± 1.8, p = 0.009) and 48 h (3.0 ± 1.2 vs. 3.8 ± 1.6, p = 0.018) after surgery compared to the control group. Total opioid consumption was reduced by 30% in the Mg group during the same period (p = 0.024 and 0.038, respectively). Patients in the Mg group required less additional doses of rocuronium (0 vs. 6 doses, p = 0.025). Adequate IOM recordings were successfully obtained for all patients, and abnormal IOM results denoting warning criteria (amplitude decrement > 50%) were similar. Total intravenous anesthesia with MgSO4 combined with opioid-based conventional pain control enables intraoperative patient immobilization without the need for additional neuromuscular blocking drugs and reduces pain intensity and analgesic requirements for 48 h after spine surgery, which is not achieved with only opioid-based protocol.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21e004b634a97f5b9a713ae1b2cd7024 https://pubmed.ncbi.nlm.nih.gov/34640307 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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