White matter correlates of cognitive flexibility in youth with bipolar disorder and typically developing children and adolescents
| Autor: | Gracie A. Jenkins, Kerri L. Kim, Lena L.A. DeYoung, Heather A. MacPherson, Anastacia Y. Kudinova, Daniel P. Dickstein, Elana Schettini, Christine M. Barthelemy, Petya D. Radoeva, Anna C. Gilbert |
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| Rok vydání: | 2020 |
| Předmět: |
Bipolar Disorder
Adolescent Neuroscience (miscellaneous) Article White matter 03 medical and health sciences Typically developing Cognition 0302 clinical medicine Neuroimaging Fractional anisotropy medicine Humans Radiology Nuclear Medicine and imaging Bipolar disorder Child Cognitive flexibility medicine.disease White Matter White matter microstructure 030227 psychiatry Psychiatry and Mental health Diffusion Tensor Imaging medicine.anatomical_structure Case-Control Studies Psychology 030217 neurology & neurosurgery Diffusion MRI Clinical psychology |
| Zdroj: | Psychiatry Res Neuroimaging |
| ISSN: | 0925-4927 |
| DOI: | 10.1016/j.pscychresns.2020.111169 |
| Popis: | Prior studies using behavioral tasks and neuroimaging have shown that children and adolescents with bipolar disorder (BD) have deficits in cognitive flexibility (CF)—defined as adaptation to changing rewards and punishments. However, no study, to our knowledge, has examined the white matter microstructural correlates of CF in youth with BD. To address this gap, we examined the relationship between CF assessed with the Cambridge Neuropsychological Testing Automated Battery (CANTAB)’s Intra-Extra Dimensional Set Shift task (ID/ED) and diffusion tensor imaging analyzed with FSL’s preprocessing tools and Tract-Based Spatial Statistics (TBSS). We found a significantly different relationship between microstructural integrity of multiple white matter regions and CF performance in BD (n=28) and age-matched typically developing control (TDC) youths (n=26). Evaluation of the slopes of linear regressions in BD vs. TDC (ID/ED Simple Reversal error rate vs. fractional anisotropy) revealed significantly different slopes across the groups, indicating an aberrant relationship between CF and underlying white matter microstructure in youth with BD. These results underscore the importance of examining specific CF-neuroimaging relationships in BD youth. Future longitudinal studies could seek to define the white matter microstructural trajectories in BD vs. TDC, and relative to CF deficits and BD illness course. |
| Databáze: | OpenAIRE |
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