The Association of Race With Childhood Uveitis
| Autor: | Carolyn Drews-Botsch, Courtney McCracken, Kirsten Jenkins, Larry B. Vogler, Sheila T. Angeles-Han, Sampath Prahalad, Daneka Stryker, Steven Yeh, Kelly Rouster-Stevens, Scott R. Lambert, Curtis Travers |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Georgia Visual acuity Adolescent Bilateral Disease Visual Acuity Severe disease Disease Article Uveitis Infectious uveitis Risk Factors Ophthalmology Prevalence medicine Humans Child Retrospective Studies business.industry Racial Groups Retrospective cohort study medicine.disease Intermediate uveitis Female medicine.symptom business Follow-Up Studies |
| Zdroj: | American Journal of Ophthalmology. 160:919-928.e1 |
| ISSN: | 0002-9394 |
| Popis: | To identify risk factors for a severe uveitis course among children with noninfectious uveitis.Retrospective cohort study.This was a retrospective analysis of a prospectively collected database. Records of 94 children with uveitis were reviewed at enrollment and every 3-6 months (2011-2015). Severe uveitis was defined as a history of ocular complications or a visual acuity (VA) of ≤20/200. Children were compared by disease, VA, complications, and race. Regression models were used to model risk factors for severe disease. When examining race, we focused on non-Hispanic African-American and non-Hispanic white children only.Of 85 children with uveitis and complete ocular examinations, 27 (32%) had a history of a VA of ≤20/200. A subanalysis of non-Hispanic African-American and white children showed an increased prevalence of VA ≤20/200 in non-Hispanic African-Americans (18/25; 72% vs 4/43; 9%). Non-Hispanic African-Americans were more likely to be diagnosed at an older age (P = .030) and to have intermediate uveitis (P = .026), bilateral disease (P = .032), a history of VA ≤20/50 (P = .002), VA ≤20/200 (P .001), and a higher rate of complications (P .001). On multivariable analysis, non-Hispanic African-American race was a significant predictor of blindness (OR = 31.6, 95% CI 5.9-168.5, P .001), after controlling for uveitis duration. Non-Hispanic African-Americans also developed 2.2 times more unique complications per year of disease than non-Hispanic whites when controlling for uveitis type and duration.There appear to be racial differences in the outcomes of children with uveitis. Non-Hispanic African-American children with non-juvenile idiopathic arthritis-associated uveitis may have worse visual outcomes with increased vision loss and ocular complications. These findings highlight the need for future studies in minority populations. |
| Databáze: | OpenAIRE |
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